ABSTRACT
Network construction technology is the basis for network pharmacology research. Data originated from experiment, database and computational prediction can be used to construct drugome network,diseaseome network and molecular interactome net?work. The molecular network construction for the complex diseases represented by Alzheimer′s disease(AD)could be used to identify the important targets,pathogenesis and drug action mechanism,and guide drug development and drug reposition. This paper reviews techniques for molecular network construction in network pharmacology study.
ABSTRACT
The technology of network analysis,based on a variety of disciplines theory,is the core technology in the research of network pharmacology,through which we can mine specified information from molecular networks from multi-angle and multi-level. It has been used to investigate and obtain valuable information about the ingredients/drugs with specific pharmacological effects ,the key nodes,modules and motifs with specific biological function,and physiological mechanism of drug action,pathogenesis of dis?ease,or biomarker of disease,especially for the complex disease represented by Alzheimer′s disease(AD). In this paper,the general techniques of network analysis in network pharmacology study are reviewed.